Showing posts with label nosocomial infections. Show all posts
Showing posts with label nosocomial infections. Show all posts

Clostridium difficile Spore-Macrophage Interactions: Spore Survival

Clostridium difficile is the main cause of nosocomial infections including antibiotic associated diarrhea, pseudomembranous colitis and toxic megacolon. During the course of Clostridium difficile infections (CDI), C. difficile undergoes sporulation and releases spores to the colonic environment. The elevated relapse rates of CDI suggest that C. difficile spores has a mechanism(s) to efficiently persist in the host colonic environment.