Inhibition of Candida parapsilosis Fatty Acid Synthase (Fas2) Induces Mitochondrial Cell Death in Serum

Candida parapsilosis is a human opportunistic pathogen associated with significant morbidity and mortality, especially in immunocompromised individuals such as premature, low-birthweight neonates. In prior studies researchers have indicated that C. parapsilosis effectively utilizes fatty acids/lipids for growth and virulence.
Authors now show that inhibition of the fatty acid synthase (Fas2) results in a hypersensitivity to serum, indicating that yeast cell survival and replication in serum medium or in vivo is dependent on Fas2. Serum hypersensitivity of Fas2-inhibited yeast cells is due to mitochondrial mediated dysregulation of metabolism. Thus, authors conclude that Fas2 is candidate antifungal target to combat disseminated fungal infections.

Original Source:

No comments:

Post a Comment